http://theparrishlab.com/teaching daily 0.75 2025-09-25 http://theparrishlab.com/researchoverview daily 1.0 2025-09-25 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/5073f4d9-993c-4455-b8ca-7171236d8ae1/heatwave+snapshot.png Research Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1558127490197-843JBDY34FHG08COK4YZ/PLC-GFP+PNG.png Research Overview https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445990469826-QOZ8DDDYEH7E9UGK371Z/dendrite+growth.png Research Overview https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/f7286470-bb81-41af-9f14-5943ac422ec0/Axon+length+schematic.png Research Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/166e5061-c89d-4d18-ba22-c58575707146/mos+neurons.png Research Overview - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445382772834-K9AKJF6FONQR4Z3QQMCN/48h-colorized-opacity-invert.jpg Research Overview http://theparrishlab.com/dendrite-substrate daily 0.75 2015-10-28 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445627464706-DD59BZSZAPL0IP2O2T20/dendrite-epidermis+interactions.png Dendrite-substrate interactions Drosophila larval sensory dendrites (green) grow over a monolayer of epithelial cells (gray) in a mostly two-dimensional plane, attached to a collagen-rich basement membrane (BM, tan) along the basal surface of epithelial cells by virtue of neuronal Integrin (magenta) and Ret (blue). The basement membrane is likewise tethered to the epidermis by epithelial Integrins. The majority of dendrites are positioned at the basal plasma membrane of epithelial cells (BM-attached dendrites; shown at high magnification in a TEM micrograph at right), but a small portion of dendrites become embedded in the epidermis. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445540320408-TQW0L4M9E1D9CI76R5UJ/scalar+expansion.png Dendrite-substrate interactions Scalar expansion of dendrite arbors. As animals grow, expansion of dendrite arbors and their substrate must be coordinated to maintain receptive field coverage. (A) Goldfish ganglion cells maintain constant coverage of the growing retina. Dendritic territories (shaded polygons) and cell bodies (black oval) are depicted for Type 1.2 ganglion cells from two fish, one 3.9 cm in length, the other 14 cm in length. Adapted from (Hitchcock, 1987). (B) Drosophila somatosensory neurons establish dendritic coverage of the body wall by Day 2 of development and maintain this coverage even as larvae grow more than 10-fold in linear dimensions. Confocal images show dendrite arbors on Day 1, 2 and 4 of development; dendritic territories of individual neurons are shaded. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1442612189332-9NCVQHT94KQVC9OTQ6RW/101201+nrx+ppk.lif+-+Image022-2.png Dendrite-substrate interactions http://theparrishlab.com/who-we-are daily 0.75 2022-10-29 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/865216a2-fac9-4bd0-a435-af51fa7376e2/HuangJessicaphoto.jpeg Who We Are - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/6b3080ee-3618-4098-9001-4fd5fd44e6aa/ORG_DSC00553.JPG Who We Are - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/37ba580e-2ff7-4222-a35a-f41bf1dd7504/headshot-AmyPlatenkamp.jpeg Who We Are - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/e38e83e6-7007-4cc0-b0ec-c1ff55fda0e6/federico+photo.jpg Who We Are - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/2841099c-04f1-4c2f-8762-4d6c7eb8dadd/ChangYin.jpg Who We Are - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://theparrishlab.com/contact-1 daily 0.75 2019-09-24 http://theparrishlab.com/publications daily 0.75 2025-09-25 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445295489316-TMML3LNZPCC3C24O5CQ4/RNAi+screen.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1442618706166-PMKO7Q9MZE3UM02EYDNV/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/609a74b1-affb-44b5-9f7f-a13649715ff2/Tao.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/d477b098-aa57-4c74-a068-c2ae2f7d75c2/Yoshino+Dev+Cell+Preview+Fig+1v2.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1535746631061-FW4M0WIJW7IRM37NXW0U/mboc.2018.29.issue-12.cover.jpg Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1532115286786-OAMDTX382XSJQAEYOI1P/Untitled-1.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/07ebe4ed-d36b-450f-acba-a5ade1649c3a/frontiers+ensheathment.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445292780928-5M3O3BGSMPWVNTPQ1E1D/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/8418dccc-fcaf-4d38-9e7b-8bf51988da22/Yoshino+2022+model.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1442614399450-OQY3OE3H2M1WQSOBBBD6/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/328e1650-173a-48b2-af09-dc4dc1e8568f/Drpr+model.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/d4c719ef-53fd-40b5-bffe-74a15c12f0cb/mir-87-shortest.jpg Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1531930729099-E1HH54U3MAFJXF45FKYV/Screen+Shot+2018-07-18+at+6.17.00+PM.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1454657101684-M35CXAUKI6ZXZOFXMQ7D/sema+paper+2.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1531931845153-2G4VU7HPPT6XEO684FTB/Screen+Shot+2018-07-18+at+6.36.58+PM.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/a40580fe-a316-4b7c-8e32-676f744f17f6/mir-14+image+v2.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1540357719944-SYEYVTYLCX45W18IOJRI/read+depth+figure4_180417a.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1531931012342-PIEKQTBF4UI9Y0BQOBGI/Screen+Shot+2018-07-18+at+6.22.02+PM.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445290423505-E5VIDOHTJA64OACV2XTN/2011+Wen+et+al+MCN_Page_1.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445294472141-WT88H8I42K63UJ3KJU76/hpo+trc+wts.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1532111472742-7UFCC7YDTDOYHUR31H8O/Screen+Shot+2018-07-20+at+8.24.33+PM.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1442615575286-GL9RCS3921DXCA68ABPD/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445292211875-H6F53OKXJYU6ZUZP4FPE/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/785e2478-0e34-4aad-b500-f286bacce3ab/Yoshino+thermo+Figure.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1452193999704-50WLFR06M32ZNRPNV4IV/path+CNS.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1442618096394-YM88HE27RZP3JIYOWN0L/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1535746417113-21K1K0OL2TB8J1AOEP0R/cover.tif.jpg Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/69b9ee77-f54c-4daf-a24a-a5f9775ff532/Aedes+Anatomy+figure.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/b40f9e17-bf50-4854-9e8e-0c9e9506d1d2/Axon+length.png Publications - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1531929943042-E0B8E80U03ZTVSK7002Q/Screen+Shot+2018-07-18+at+6.05.18+PM.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1455921793222-7PAUX5N0KU45O1NSN4WE/image-asset.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1538340834413-HK4QVPIHY1LVMLPF5YEC/Model+figure.png Publications https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445289596452-OIHSM4S97GKBP67FY8Z6/Rop-Sec6.png Publications http://theparrishlab.com/growth-control daily 0.75 2022-10-28 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445539926828-B581QK180ZP206D66MEJ/image-asset.png Growth control in neurons genetic screen for mutations that cause defects in dendrite compartmentalization. Representative neurons are shown for the following: (A) wild type control, (b) jj329, which affects proximal-distal positioning of dendrite branches, (C) jj472, which affects elongation of terminal dendrites but not major dendrites, and (D) jj835, which is required for growth of terminal dendrites but not major dendrites. Traces below neurons depict major dendrites in red and higher order dendrites in gray. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445539890431-SPVLJMZWLKDRLIR8JM05/image-asset.png Growth control in neurons (A) Path is required for dendrite growth in somatosensory neurons. Representative images are shown for somatosensory neuron dendrite arbors in wild type and path mutant larvae. (B) Putative pathway for Path-mediated growth control. Path regulates translational capacity in neurons via an unknown pathway that might involve TORC1. (C) Path control of translational capacity. Even in the absence of path function, cells have residual translation capacity that is sufficient to support growth of most cell types under laboratory conditions. A prediction of this model is that stresses that compromise translation efficiency should sensitize cells to a requirement for path function. https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445538989102-CGUIGTZEOKVEUMTZHEHE/scaling+3.png Growth control in neurons http://theparrishlab.com/research-support daily 0.75 2025-09-25 http://theparrishlab.com/homeostatic-control-of-neuronal-activity daily 0.75 2015-10-27 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445987798701-VF0FLHCKW8Y3DFKUF162/Single+Cell+workflow.png Transcriptomics of sensory neurons https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1445304258920-1FZCK4OYPO0HDHI9H215/heat+map.png Transcriptomics of sensory neurons http://theparrishlab.com/join-the-lab daily 0.75 2022-10-28 https://images.squarespace-cdn.com/content/v1/55f875f9e4b03eacc66a01f1/1558128105890-YI1EOJU56TAMGJ07OGD3/Cropped-UW-LSB-SW-Entry.jpg Join the Lab